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Master theses

Current and past ideas and concepts for Master Theses.

Phase amplitude coupling in preclinical models of disease


Electrical activity of the brain has been measured for years with electroencephalography (EEG). Recently, a physiological coupling has been observed between the phase of slow waves and the amplitude of fast waves of the brain. This phase-amplitude coupling (PAC) plays a role in memory and is disrupted in patients with Alzheimer’s disease and epilepsy. As a thesis student, you will have the opportunity to use animal and patient EEG-data to evaluate different methods to calculate PAC and assess the effect of treatment on PAC.

Kind of work

- Implementation of different measures of phase-amplitude coupling in Python
- Depending on the student’s interest, the focus can shift from application of PAC in different datasets to the implementation and development of PAC algorithms and assess their value in a single dataset.

Framework of the Thesis

The AIMS research group ( is an interdisciplinary research group within VUB that includes engineers, neurologists and psychologists. Its aim is to characterise and improve our understanding of how neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, affect brain functioning.

This project is performed in close collaboration with the Faculty of Medicine and Pharmacy (Maxime Vande Vyver, Dimitri De Bundel and Ilse Smolders).

Number of Students


Expected Student Profile

• A strong interest in neuroimaging
• A strong interest in the inner workings of the brain
• Good programming skills


Prof. Dr. Ir. Jeroen Van Schependom

+32 (0)02 629 104

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