ETRO VUB
About ETRO  |  News  |  Events  |  Press  |  Vacancies  |  Contact  
Home Research Education Industry Publications ETRO Team

ETRO Publications

Full Details

Conference Publication

NIR fluorescence lifetime sensing through a multimode fiber for intravascular molecular probing

Host Publication: SPIE Photonics Europe 2016

Authors: H. Ingelberts, M. Kuijk, S. Hernot, P. Debie and T. Lahoutte

Publisher: SPIE

Publication Date: Apr. 2016

Number of Pages: 7


Abstract:

Coronary artery disease (CAD) contributes to millions of deaths each year. The identification of vulnerable plaques is essential to the diagnosis of CAD but is challenging. Molecular probes can improve the detection of these plaques using intravascular imaging methods. Fluorescence lifetime sensing is a safe and robust method to image these molecular probes. We present two variations of an optical system for intravascular near-infrared (NIR) fluorescence lifetime sensing through a multimode fiber. Both systems are built around a recently developed fast and efficient CMOS detector, the current-assisted photonic sampler (CAPS) that is optimized for sub-nanosecond NIR fluorescence lifetime sensing. One system mimics the optical setup of an epifluorescence microscope while the other uses a practical fiber optic coupler to separate fluorescence excitation and emission. We test both systems by measuring the lifetime of several NIR dyes in DMSO solutions and we show that these systems are capable of detecting lifetimes of solutions with concentrations down to 370 nM and this with short acquisition times. These results are compared with time-correlated single photon counting (TCSPC) measurements for reference. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Other Reference Styles
Current ETRO Authors

Mr. Hans Ingelberts

+32 (0)02 629 139

hingelbe@etrovub.be

more info

Prof. Maarten Kuijk

+32 (0)02 629 299

mkuijk@etrovub.be

more info

Other Publications

• Journal publications

IRIS • LAMI • AVSP

• Conference publications

IRIS • LAMI • AVSP

• Book publications

IRIS • LAMI • AVSP

• Reports

IRIS • LAMI • AVSP

• Laymen publications

IRIS • LAMI • AVSP

• PhD Theses

Search ETRO Publications

Author:

Keyword:  

Type:








- Contact person

- IRIS

- AVSP

- LAMI

- Contact person

- Thesis proposals

- ETRO Courses

- Contact person

- Spin-offs

- Know How

- Journals

- Conferences

- Books

- Vacancies

- News

- Events

- Press

Contact

ETRO Department

info@etro.vub.ac.be

Tel: +32 2 629 29 30

©2017 • Vrije Universiteit Brussel • ETRO Dept. • Pleinlaan 2 • 1050 Brussels • Tel: +32 2 629 2930 (secretariat) • Fax: +32 2 629 2883 • WebmasterDisclaimer