Registration strategies for multi-modal whole-body MRI mosaicing
This publication appears in: Magnetic Resonance in Medicine
Authors: J. Ceranka, M. Polfliet, F. Lecouvet, N. Michoux, J. De Mey and J. Vandemeulebroucke
Publication Date: Mar. 2018
Purpose: To test and compare different registration approaches for performing whole-body diffusion-weighted (wbDWI) image station mosaicing, and its alignment to corresponding anatomical T
1 whole-body image. Methods: Four different registration strategies aiming at mosaicing of diffusion-weighted image stations, and their alignment to the corresponding whole-body anatomical image, were proposed and evaluated. These included two-step approaches, where diffusion-weighted stations are first combined in a pairwise (Strategy 1) or groupwise (Strategy 2) manner and later non-rigidly aligned to the anatomical image a direct pairwise mapping of DWI stations onto the anatomical image (Strategy 3) and simultaneous mosaicing of DWI and alignment to the anatomical image (Strategy 4). Additionally, different images driving the registration were investigated. Experiments were performed for 20 whole-body images of patients with bone metastases. Results: Strategies 1 and 2 showed significant improvement in mosaicing accuracy with respect to the non-registered images (P < 0.006). Strategy 2 based on ADC images increased the alignment accuracy between DWI stations and the T
1 whole-body image (P = 0.0009). Conclusions: A two-step registration strategy, relying on groupwise mosaicing of the ADC stations and subsequent registration to T
1, provided the best compromise between whole-body DWI image quality and multi-modal alignment. Magn Reson Med 79:1684, 2018.