ETRO VUB
About ETRO  |  News  |  Events  |  Vacancies  |  Contact  
Home Research Education Industry Publications About ETRO

ETRO Publications

Full Details

Conference Publication

Accurate Bolus Arrival Time Estimation using Piecewise Linear Model Fitting

Host Publication: SPIE

Authors: E. Abdou, J. De Mey, M. De Ridder and J. Vandemeulebroucke

Publication Year: 2017

Number of Pages: 6


Abstract:

Dynamic contrast-enhanced computed tomography (DCE-CT) is an emerging radiological technique, which consists in acquiring a rapid sequence of CT images, shortly after the injection of an intravenous contrast agent. The passage of the contrast agent in a tissue results in a varying CT intensity over time, recorded in time-attenuation curves (TACs), which can be related to the contrast supplied to that tissue via the supplying artery to estimate the local perfusion and permeability characteristics. The time delay between the arrival of the contrast bolus in the feeding artery and the tissue of interest, called the bolus arrival time (BAT), needs to be determined accurately to enable reliable perfusion analysis. Its automated identification is however highly sensitive to noise. We propose an accurate and efficient method for estimating the BAT from DCE-CT images. The method relies on a piecewise linear TAC model with four segments and suitable parameter constraints for limiting the range of possible values. The model is fitted to the acquired TACs in a multiresolution fashion using an iterative optimization approach. The performance of the method was evaluated on simulated and real perfusion data of lung and rectum tumours. In both cases, the method was found to be stable, leading to average accuracies in the order of the temporal resolution of the dynamic sequence. For reasonable levels of noise, the results were found to be comparable to those obtained using a previously proposed method, employing a full search algorithm, but requiring an order of magnitude more computation time.

Other Reference Styles
Current ETRO Authors

Dr. Ir. Jef Vandemeulebroucke

+32 (0)02 629 103

jefvdmb@etrovub.be

more info

Other Publications

• Journal publications

IRIS • LAMI • AVSP

• Conference publications

IRIS • LAMI • AVSP

• Book publications

IRIS • LAMI • AVSP

• Reports

IRIS • LAMI • AVSP

• Laymen publications

IRIS • LAMI • AVSP

• PhD Theses

Search ETRO Publications

Author:

Keyword:  

Type:








- Contact person

- IRIS

- AVSP

- LAMI

- Contact person

- Thesis proposals

- ETRO Courses

- Contact person

- Spin-offs

- Know How

- Journals

- Conferences

- Books

- Vacancies

- News

- Events

- Press

Contact

ETRO Department

info@etro.vub.ac.be

Tel: +32 2 629 29 30

©2019 • Vrije Universiteit Brussel • ETRO Dept. • Pleinlaan 2 • 1050 Brussels • Tel: +32 2 629 2930 (secretariat) • Fax: +32 2 629 2883 • WebmasterDisclaimer