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Quantification of blood velocity from time-resolved CT angiography on a 256-slice CT

Host Publication: ECR 2018 - BOOK OF ABSTRACTS

Authors: P. Boonen, N. Buls, J. Vandemeulebroucke, G. Van Gompel, D. Aerden and J. De Mey

Publication Date: Feb. 2018


Abstract:

Purpose: To quantify the blood velocity in the arteries of the lower extremities and to investigate the correlation with peripheral arterial disease (PAD). Methods and Materials: 7 Patients with suspicion of PAD underwent timeresolved Computed Tomography Angiography (CTA) in addition to their standard run-off CTA, consisting of 18 repeated axial acquisitions at 2s interphase delay at the level of the calves with 16cm collimation (Revolution CT, GE Healthcare). Image data was processed using in-house developed processing tools. Motion during the acquisitions was compensated by applying registration, after which the anterior tibial artery, posterior tibial artery and peroneal artery were automatically segmented by identifying large intensity changes over time. Subsequently, blood velocity was quantified in the arteries by creating time attenuation curves (TAC) of the arterial cross-sections in every slice and determining the time to peak (TTP). Results: The described method led to plausible velocity estimations in all arteries (n=18) for patients that were considered healthy (n=3). For pathological patients (n=4), only 12 out of 22 arteries could be quantified due to suboptimal bolus arrival, severe calcification or occlusions. For arteries of healthy patients, blood velocity was normally distributed (p=0.282) with a median value of 82.3 mm/s (95% CI= 55.5- 89.9 mm/s). Blood velocity in arteries of pathological patients was observed to be significantly lower, 30.7 mm/s (95% CI= 27.4ᇁ.7 mm/s), p<0.01. Conclusion: Time-resolved CT data allows to quantify blood velocity in the arteries of the lower extremities. In heavily occluded arteries, the contrast was insufficient in order to quantify velocity.

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