This article presents practical design considerations and methodologies for a 28-GHz front-end module (FEM) in 22-nm fully depleted silicon on insulator (FD-SOI) CMOS technology for the fifth generation (5G) wireless communication. The design adopts a gain-boosting technique that is comprehensively analyzed with a transformer-based stacked-FET power amplifier (PA). Then, the co-design of the transmit/receive (T/R) switch with the PA and low-noise amplifier (LNA) is investigated, and an electrostatic-discharge (ESD)-aware T/R switch incorporating PA circuitry is proposed to leverage the Tx- and Rx-mode performance. Moreover, the robustness of standalone PA and Tx-mode FEM is simulated and experimentally verified. Furthermore, the ground return paths and supply parasitic paths of the adopted single-ended LNA together with the proposed T/R switch are studied, properly simulated, and assessed. Finally, the proposed PA topology is first verified standalone, exhibiting 32-dB power gain (Gp), an 18.2-dBm output 1-dB compression point (OP1 dB), and a 31.1&#x0025 power-added efficiency (PAE) at OP1 dB (PAE1 dB). Using this PA in the FEM yields a Tx-mode OP1 dB/PAE1 dB of 16 dBm/19.4&#x0025, and an average output power (Poutavg)/PAE of 10.1 dBm/8.3&#x0025 for a 100-MHz bandwidth 256-QAM single-carrier signal at an error-vector magnitude (EVM) of -30 dB. In the Rx mode, noise figure (NF) and input-referred third-order intercept point (IIP3) are 3.2 and -5.4 dBm, respectively. A 2-kV human-body model (HBM) ESD protection of the FEM is predicted in transient simulations and measured with transmission line pulse (TLP) tests.