Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immuno-senescence (IS) - predominantly driven by cytomegalovirus (CMV) - has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty. 173 persons aged 80 to 99 years were enrolled. Pre-frailty was defined according to Fried's criteria. Anti-CMV IgG and serum IL-6 were measured using Architect iSystem and Luminex, respectively. T-cell phenotypes were determined using flow cytometry. The prevalence of pre-frailty was 52.6%, increased with age (p=0.001), and was greater in men than women (p=0.044). No relationship was found between pre-frailty and positive CMV serology. Further, CMV-seropositivity was significantly associated with less na{\"i}ve cells, more memory and senescence-prone phenotypes (all p<0.001). After adjusting for potential confounders, only IL-6, age and sex were predictive of pre-frailty. We conclude that the presence of pre-frailty is independent from CMV infection in very old subjects.
Dinh, HC, Bautmans, I, Beyer, I, Mets, T, Onyema, OO, Forti, LN, Renmans, W, Vander Meeren, S, Jochmans, K, Vermeiren, S, Vella-Azzopardi, R, Njemini, R, Verte, D, Petrovic, M, De Donder, L, Kardol, T, Rossi, G, Clarys, P, Scafoglieri, A, Cattrysse, E, de Hert, P & Jansen, B 2019, 'Association between Immunosenescence Phenotypes and pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role?', The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 4, pp. 480-488. https://doi.org/10.1093/gerona/gly135
Dinh, H. C., Bautmans, I., Beyer, I., Mets, T., Onyema, O. O., Forti, L. N., Renmans, W., Vander Meeren, S., Jochmans, K., Vermeiren, S., Vella-Azzopardi, R., Njemini, R., Verte, D., Petrovic, M., De Donder, L., Kardol, T., Rossi, G., Clarys, P., Scafoglieri, A., ... Jansen, B. (2019). Association between Immunosenescence Phenotypes and pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role? The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 74(4), 480-488. https://doi.org/10.1093/gerona/gly135
@article{2a1e93d5781a477e807666c1b19e2c61,
title = "Association between Immunosenescence Phenotypes and pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role?",
abstract = "Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immuno-senescence (IS) - predominantly driven by cytomegalovirus (CMV) - has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty. 173 persons aged 80 to 99 years were enrolled. Pre-frailty was defined according to Fried's criteria. Anti-CMV IgG and serum IL-6 were measured using Architect iSystem and Luminex, respectively. T-cell phenotypes were determined using flow cytometry. The prevalence of pre-frailty was 52.6%, increased with age (p=0.001), and was greater in men than women (p=0.044). No relationship was found between pre-frailty and positive CMV serology. Further, CMV-seropositivity was significantly associated with less na{\"i}ve cells, more memory and senescence-prone phenotypes (all p<0.001). After adjusting for potential confounders, only IL-6, age and sex were predictive of pre-frailty. We conclude that the presence of pre-frailty is independent from CMV infection in very old subjects.",
keywords = "Immunosenescence Phenotypes , pre-frailty , Cytomegalovirus , Frailty , mortality risk, Senescence, Lymphocytes, Robust, Inflammation",
author = "Dinh, {Hung Cao} and Ivan Bautmans and Ingo Beyer and Tony Mets and Onyema, {Oscar Okwudiri} and Forti, {Louis Nuvagah} and Wim Renmans and {Vander Meeren}, Sam and Kristin Jochmans and Sofie Vermeiren and Roberta Vella-Azzopardi and Rose Njemini and Dominique Verte and Mirko Petrovic and {De Donder}, Liesbeth and Tinie Kardol and Gina Rossi and Peter Clarys and Aldo Scafoglieri and Erik Cattrysse and {de Hert}, Paul and Bart Jansen",
note = "{\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = apr,
doi = "10.1093/gerona/gly135",
language = "English",
volume = "74",
pages = "480--488",
journal = "The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "4",
}