Pieter Libin, Lize Cuypers, Peter Simmonds, Ann Nowe, Jorge Muñoz-Jordán, Luiz Alcantara, Anne-Mieke Vandamme, Gilberto Santiago, Kristof Theys
Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus{\textquoteright}s ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV{\textquoteright}s current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.
Libin, P, Cuypers, L, Simmonds, P, Nowe, A, Muñoz-Jordán, J, Alcantara, L, Vandamme, A, Santiago, G & Theys, K 2018, 'Time to Harmonize Dengue Nomenclature and Classification', Viruses, vol. 10, no. 10, 569. https://doi.org/10.3390/v10100569
Libin, P., Cuypers, L., Simmonds, P., Nowe, A., Muñoz-Jordán, J., Alcantara, L., Vandamme, A., Santiago, G., & Theys, K. (2018). Time to Harmonize Dengue Nomenclature and Classification. Viruses, 10(10), Article 569. https://doi.org/10.3390/v10100569
@article{8c085c622bbc4bcbb0c447b03babda1d,
title = "Time to Harmonize Dengue Nomenclature and Classification",
abstract = "Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus{\textquoteright}s ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV{\textquoteright}s current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.",
keywords = "Classification, Dengue virus, Diversity, Nomenclature",
author = "Pieter Libin and Lize Cuypers and Peter Simmonds and Ann Nowe and Jorge Mu{\~n}oz-Jord{\'a}n and Luiz Alcantara and Anne-mieke Vandamme and Gilberto Santiago and Kristof Theys",
year = "2018",
month = oct,
day = "18",
doi = "10.3390/v10100569",
language = "English",
volume = "10",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI",
number = "10",
}