Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers expected to rise due to ageing and improved survival rates. Functional recovery from AF-related stroke is often unsatisfactory, leading to prolonged hospital stays, severe disability, and high mortality. Despite advances in AF and stroke research, the full pathophysiological and management issues between AF and stroke increasingly need innovative approaches such as artificial intelligence (AI) and machine learning (ML). Current risk assessment tools focus on static risk factors, neglecting the dynamic nature of risk influenced by acute illness, ageing, and comorbidities. Incorporating biomarkers and automated ECG analysis could enhance pathophysiological understanding. This paper highlights the need for personalised, integrative approaches in AF and stroke management, emphasising the potential of AI and ML to improve risk prediction, treatment personalisation, and rehabilitation outcomes. Further research is essential to optimise care and reduce the burden of AF and stroke on patients and healthcare systems.
TARGET consortium , Swinnen, E, Jansen, B, Degelaen, M, Omelina, L, De Raedt, S & Embrechts, E 2025, 'Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation', Trends in Cardiovascular Medicine, vol. 35, no. 4, pp. 205-211. https://doi.org/10.1016/j.tcm.2024.12.003
TARGET consortium , Swinnen, E., Jansen, B., Degelaen, M., Omelina, L., De Raedt, S., & Embrechts, E. (2025). Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation. Trends in Cardiovascular Medicine, 35(4), 205-211. https://doi.org/10.1016/j.tcm.2024.12.003
@article{61a914508a354ac090c4f01265619140,
title = "Advancing personalised care in atrial fibrillation and stroke: The potential impact of AI from prevention to rehabilitation",
abstract = "Atrial fibrillation (AF) is a complex condition caused by various underlying pathophysiological disorders and is the most common heart arrhythmia worldwide, affecting 2 % of the European population. This prevalence increases with age, imposing significant financial, economic, and human burdens. In Europe, stroke is the second leading cause of death and the primary cause of disability, with numbers expected to rise due to ageing and improved survival rates. Functional recovery from AF-related stroke is often unsatisfactory, leading to prolonged hospital stays, severe disability, and high mortality. Despite advances in AF and stroke research, the full pathophysiological and management issues between AF and stroke increasingly need innovative approaches such as artificial intelligence (AI) and machine learning (ML). Current risk assessment tools focus on static risk factors, neglecting the dynamic nature of risk influenced by acute illness, ageing, and comorbidities. Incorporating biomarkers and automated ECG analysis could enhance pathophysiological understanding. This paper highlights the need for personalised, integrative approaches in AF and stroke management, emphasising the potential of AI and ML to improve risk prediction, treatment personalisation, and rehabilitation outcomes. Further research is essential to optimise care and reduce the burden of AF and stroke on patients and healthcare systems.",
keywords = "Artificial Intelligence, Atrial Fibrillation, Burden, Digital Twins, Impact, Machine Learning, Personalised care, Significance, Stroke",
author = "{TARGET consortium} and Sandra Ortega-Martorell and Ivan Olier and Mattias Ohlsson and Lip, {Gregory Y.H.} and Eva Swinnen and Bart Jansen and M Degelaen and Lubos Omelina and {De Raedt}, Sylvie and Elissa Embrechts",
note = "Funding Information: This paper underscores the critical need for continued research and the adoption of integrative strategies to optimise AF and stroke care, ultimately aiming to mitigate the substantial burden these conditions impose on patients and healthcare systems. This research need is what gave origin to projects such as TARGET: \u201CHealth virtual twins for the personalised management of stroke related to atrial fibrillation\u201D (\u20AC10M project funded by the EU Horizon Programme) [ 56 , 57 ]. Funding Information: This study was supported by the European Union's Horizon Europe research and innovation programme under Grant Agreement No 101136244 (TARGET). Publisher Copyright: {\textcopyright} 2024",
year = "2025",
month = may,
doi = "10.1016/j.tcm.2024.12.003",
language = "English",
volume = "35",
pages = "205--211",
journal = "Trends in Cardiovascular Medicine",
issn = "1050-1738",
publisher = "Elsevier",
number = "4",
}