Campens, L., Renard, M., Trachet, B., Segers, P., Muino Mosquera, L., De Sutter, J., Sakai, L., De Paepe, A., & De Backer, J. (2015). Intrinsic cardiomyopathy in Marfan syndrome: results from in-vivo and ex-vivo studies of the Fbn1C1039G/+ model and longitudinal findings in humans. Pediatric Research, 78(3), 256-263. https://doi.org/10.1038/pr.2015.110

@article{bba8c4a27f5b407cb7c9813417379ca4,
title = "Intrinsic cardiomyopathy in Marfan syndrome: results from in-vivo and ex-vivo studies of the Fbn1C1039G/+ model and longitudinal findings in humans",
abstract = "BACKGROUND: Mild intrinsic cardiomyopathy in patients with Marfan syndrome (MFS) has consistently been evidenced by independent research groups. So far, little is known about the long-term evolution and pathophysiology of this finding.METHODS: To gain more insights into the pathophysiology of MFS-related cardiomyopathy, we performed in-vivo and ex-vivo studies of 11 Fbn1(C1039G/+) mice and 9 wild-type (WT) littermates. Serial ultrasound findings obtained in mice were correlated to the human phenotype. We therefore reassessed left ventricular (LV) function parameters over a 6-y follow-up period in 19 previously reported MFS patients, in whom we documented mild LV dysfunction.RESULTS: Fbn1(C1039G/+) mice demonstrated LV contractile dysfunction. Subsequent ex-vivo studies of the myocardium of adult mutant mice revealed upregulation of TGFβ-related pathways and consistent abnormalities of the microfibrillar network, implicating a role for microfibrils in the mechanical properties of the myocardium. Echocardiographic parameters did not indicate clinical significant deterioration of LV function during follow-up in our patient cohort.CONCLUSION: In analogy with what is observed in the majority of MFS patients, the Fbn1(C1039G/+) mouse model demonstrates mild intrinsic LV dysfunction. Both extracellular matrix and molecular alterations are implicated in MFS-related cardiomyopathy. This model may now enable us to study therapeutic interventions on the myocardium in MFS.",
keywords = "Animals, Cardiomyopathies, Cohort Studies, Disease Models, Animal, Echocardiography, Female, Humans, Immunohistochemistry, Integrins, Male, Marfan Syndrome, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Mutation, Missense, Myocardium, Phenotype, Transforming Growth Factor beta1, Ultrasonography, Ventricular Dysfunction, Left, Ventricular Function, Left",
author = "Laurence Campens and Marjolijn Renard and Bram Trachet and Patrick Segers and {Muino Mosquera}, Laura and {De Sutter}, Johan and Lynn Sakai and {De Paepe}, Anne and {De Backer}, Julie",
year = "2015",
month = sep,
doi = "10.1038/pr.2015.110",
language = "English",
volume = "78",
pages = "256--263",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}