European Alzheimer's Disease Initiative Investigators (2009). Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature Genetics, 41(10), 1094-1099. https://doi.org/10.1038/ng.439

@article{3b609d1672684c65a08b473be7c86ea9,
title = "Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease",
abstract = "The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a large genome-wide association study of 2,032 individuals from France with Alzheimer's disease (cases) and 5,328 controls. Markers outside APOE with suggestive evidence of association (P < 10(-5)) were examined in collections from Belgium, Finland, Italy and Spain totaling 3,978 Alzheimer's disease cases and 3,297 controls. Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data). Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease.",
keywords = "Alzheimer Disease/genetics, Clusterin/genetics, European Continental Ancestry Group/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Haplotypes, Humans, Polymorphism, Single Nucleotide, Receptors, Complement 3b/genetics",
author = "{European Alzheimer's Disease Initiative Investigators} and Jean-Charles Lambert and Simon Heath and Gael Even and Dominique Campion and Kristel Sleegers and Mikko Hiltunen and Onofre Combarros and Diana Zelenika and Bullido, {Maria J} and B{\'e}atrice Tavernier and Luc Letenneur and Karolien Bettens and Claudine Berr and Florence Pasquier and Nathalie Fi{\'e}vet and Pascale Barberger-Gateau and Sebastiaan Engelborghs and {De Deyn}, Peter and Ignacio Mateo and Ana Franck and Seppo Helisalmi and Elisa Porcellini and Olivier Hanon and {de Pancorbo}, {Marian M} and Corinne Lendon and Carole Dufouil and C{\'e}line Jaillard and Thierry Leveillard and Victoria Alvarez and Paolo Bosco and Michelangelo Mancuso and Francesco Panza and Benedetta Nacmias and Paola Boss{\`u} and Paola Piccardi and Giorgio Annoni and Davide Seripa and Daniela Galimberti and Didier Hannequin and Federico Licastro and Hilkka Soininen and Karen Ritchie and H{\'e}l{\`e}ne Blanch{\'e} and Jean-Fran{\c c}ois Dartigues and Christophe Tzourio and Ivo Gut and {Van Broeckhoven}, Christine and Annick Alp{\'e}rovitch and Mark Lathrop and Philippe Amouyel",
year = "2009",
doi = "10.1038/ng.439",
language = "English",
volume = "41",
pages = "1094--1099",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",
}