Antita M Adriaens, Ingeborgh E Polis, Simon T Vermeire, Tim Waelbers, Luc Duchateau, Stanislas U Sys, Sylvia Van Dorpe, Jos L Eersels, Bart De Spiegeleer, Kathelijne Peremans
UNLABELLED: The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150.METHODS: 5-HT(2A) binding was estimated with and without morphine pretreatment in 8 dogs. The 5-HT(2A) binding indices in the frontal, parietal, temporal, and occipital cortex and in the subcortical region were obtained by semiquantification.RESULTS: A significantly decreased 5-HT(2A) binding index was found in the morphine group for the right (morphine, 1.41 ± 0.06; control, 1.52 ± 0.10) and left (morphine, 1.44 ± 0.08; control, 1.55 ± 0.11) frontal cortices, with P = 0.012 and P = 0.040, respectively. No significant differences were noted for the other regions.CONCLUSION: Morphine decreased the frontocortical 5-HT(2A) availability, confirming an interaction between the 5-HTergic and the opioid systems. Whether this interaction is caused by decreased receptor density due to direct internalization or is the result of indirect actions, such as increased endogenous serotonin release, remains to be elucidated.
Adriaens, AM, Polis, IE, Vermeire, ST, Waelbers, T, Duchateau, L, Sys, SU, Van Dorpe, S, Eersels, JL, De Spiegeleer, B & Peremans, K 2012, 'The influence of morphine on cerebral 5-HT2A availability in dogs: a SPECT study', Journal of Nuclear Medicine, vol. 53, no. 12, pp. 1969-1973. https://doi.org/10.2967/jnumed.112.103796
Adriaens, A. M., Polis, I. E., Vermeire, S. T., Waelbers, T., Duchateau, L., Sys, S. U., Van Dorpe, S., Eersels, J. L., De Spiegeleer, B., & Peremans, K. (2012). The influence of morphine on cerebral 5-HT2A availability in dogs: a SPECT study. Journal of Nuclear Medicine, 53(12), 1969-1973. https://doi.org/10.2967/jnumed.112.103796
@article{64b0e2f4734d49ba98f9c92d97defda2,
title = "The influence of morphine on cerebral 5-HT2A availability in dogs: a SPECT study",
abstract = "UNLABELLED: The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150.METHODS: 5-HT(2A) binding was estimated with and without morphine pretreatment in 8 dogs. The 5-HT(2A) binding indices in the frontal, parietal, temporal, and occipital cortex and in the subcortical region were obtained by semiquantification.RESULTS: A significantly decreased 5-HT(2A) binding index was found in the morphine group for the right (morphine, 1.41 ± 0.06; control, 1.52 ± 0.10) and left (morphine, 1.44 ± 0.08; control, 1.55 ± 0.11) frontal cortices, with P = 0.012 and P = 0.040, respectively. No significant differences were noted for the other regions.CONCLUSION: Morphine decreased the frontocortical 5-HT(2A) availability, confirming an interaction between the 5-HTergic and the opioid systems. Whether this interaction is caused by decreased receptor density due to direct internalization or is the result of indirect actions, such as increased endogenous serotonin release, remains to be elucidated.",
keywords = "Animals, Brain, Dogs, Female, Morphine, Receptor, Serotonin, 5-HT2A, Tomography, Emission-Computed, Single-Photon, Journal Article, Research Support, Non-U.S. Gov't",
author = "Adriaens, {Antita M} and Polis, {Ingeborgh E} and Vermeire, {Simon T} and Tim Waelbers and Luc Duchateau and Sys, {Stanislas U} and {Van Dorpe}, Sylvia and Eersels, {Jos L} and {De Spiegeleer}, Bart and Kathelijne Peremans",
year = "2012",
month = dec,
doi = "10.2967/jnumed.112.103796",
language = "English",
volume = "53",
pages = "1969--1973",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "12",
}