There is increasing evidence to suggest that atrial fibrillation is associated with a heightened risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral infarcts, hypoperfusion, systemic inflammation, and anticoagulant therapy-induced cerebral microbleeds, have been proposed to explain the link between these conditions. An understanding of the pathogenesis of atrial fibrillation-associated cognitive decline may enable the development of treatment strategies targeted towards the prevention of dementia in atrial fibrillation patients. The aim of this review is to explore the impact that existing atrial fibrillation treatment strategies may have on cognition and the putative mechanisms linking the two conditions. This review examines how components of the 'Atrial Fibrillation Better Care pathway' (stroke risk reduction, rhythm control, rate control, and risk factor management) may influence the trajectory of atrial fibrillation-associated cognitive decline. The requirements for further prospective studies to understand the mechanistic link between atrial fibrillation and dementia and to develop treatment strategies targeted towards the prevention of atrial fibrillation-associated cognitive decline, are highlighted.
Bodagh, N, Kotadia, I, Gharaviri, A, Zelaya, F, Birns, J, Bhalla, A, Sommerville, P, Niederer, S, O'Neill, M & Williams, SE 2023, 'The Impact of Atrial Fibrillation Treatment Strategies on Cognitive Function', Journal of clinical medicine, vol. 12, no. 9, 3050, pp. 1-19. https://doi.org/10.3390/jcm12093050
Bodagh, N., Kotadia, I., Gharaviri, A., Zelaya, F., Birns, J., Bhalla, A., Sommerville, P., Niederer, S., O'Neill, M., & Williams, S. E. (2023). The Impact of Atrial Fibrillation Treatment Strategies on Cognitive Function. Journal of clinical medicine, 12(9), 1-19. Article 3050. https://doi.org/10.3390/jcm12093050
@article{ff3871f305e14bd88db1e3d5a739ea30,
title = "The Impact of Atrial Fibrillation Treatment Strategies on Cognitive Function",
abstract = "There is increasing evidence to suggest that atrial fibrillation is associated with a heightened risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral infarcts, hypoperfusion, systemic inflammation, and anticoagulant therapy-induced cerebral microbleeds, have been proposed to explain the link between these conditions. An understanding of the pathogenesis of atrial fibrillation-associated cognitive decline may enable the development of treatment strategies targeted towards the prevention of dementia in atrial fibrillation patients. The aim of this review is to explore the impact that existing atrial fibrillation treatment strategies may have on cognition and the putative mechanisms linking the two conditions. This review examines how components of the 'Atrial Fibrillation Better Care pathway' (stroke risk reduction, rhythm control, rate control, and risk factor management) may influence the trajectory of atrial fibrillation-associated cognitive decline. The requirements for further prospective studies to understand the mechanistic link between atrial fibrillation and dementia and to develop treatment strategies targeted towards the prevention of atrial fibrillation-associated cognitive decline, are highlighted.",
author = "Neil Bodagh and Irum Kotadia and Ali Gharaviri and Fernando Zelaya and Jonathan Birns and Ajay Bhalla and Peter Sommerville and Steven Niederer and Mark O'Neill and Williams, {Steven E}",
note = "Funding Information: This research is part of the British Heart Foundation Centre for Research Excellence at the University of Edinburgh [RE/18/5/34216]. SEW is supported by the British Heart Foundation [FS/20/26/34952]. The authors acknowledge the support of the British Heart Foundation [RG/20/4/34803], [PG/19/44/34368]. IK is supported by the British Heart Foundation [FS/CRTF/21/24166]. Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
month = apr,
day = "22",
doi = "10.3390/jcm12093050",
language = "English",
volume = "12",
pages = "1--19",
journal = "Journal of clinical medicine",
issn = "2077-0383",
publisher = "MDPI",
number = "9",
}