Pulmonary vein (PV) isolation (PVI) improves freedom from atrial tachyarrhythmia recurrences in patients with paroxysmal and persistent atrial fibrillation (AF).1 However, PVI has a limited success rate in persistent AF patients and ablation techniques adjunctive to PVI isolating non-PV triggers remain an area of debate in these patients.1 Recently, there has been a growing interest in the electrical and anatomical role of the left atrial appendage (LAA) in triggering and sustaining AF, particularly in persistent AF patients or after repeated AF ablation procedures.2 Whether isolation of triggers originating from the LAA or substrate modification caused by LAA isolation (LAAI) is the underlying mechanism for AF recurrence prevention is still unknown.
Gharaviri, A, Pezzuto, S, Potse, M, Verheule, S, Conte, G, Krause, R, Schotten, U & Auricchio, A 2021, 'Left Atrial Appendage Electrical Isolation Reduces Atrial Fibrillation Recurrences: A Simulation Study', Circulation: Arrhythmia and Electrophysiology, vol. 14, no. 1, e009230, pp. 105-107. https://doi.org/10.1161/CIRCEP.120.009230, https://doi.org/10.1161/CIRCEP.120.009230
Gharaviri, A., Pezzuto, S., Potse, M., Verheule, S., Conte, G., Krause, R., Schotten, U., & Auricchio, A. (2021). Left Atrial Appendage Electrical Isolation Reduces Atrial Fibrillation Recurrences: A Simulation Study. Circulation: Arrhythmia and Electrophysiology, 14(1), 105-107. Article e009230. https://doi.org/10.1161/CIRCEP.120.009230, https://doi.org/10.1161/CIRCEP.120.009230
@article{b6b4cc18bf044ca996b0ca17751e84ae,
title = "Left Atrial Appendage Electrical Isolation Reduces Atrial Fibrillation Recurrences: A Simulation Study",
abstract = "Pulmonary vein (PV) isolation (PVI) improves freedom from atrial tachyarrhythmia recurrences in patients with paroxysmal and persistent atrial fibrillation (AF).1 However, PVI has a limited success rate in persistent AF patients and ablation techniques adjunctive to PVI isolating non-PV triggers remain an area of debate in these patients.1 Recently, there has been a growing interest in the electrical and anatomical role of the left atrial appendage (LAA) in triggering and sustaining AF, particularly in persistent AF patients or after repeated AF ablation procedures.2 Whether isolation of triggers originating from the LAA or substrate modification caused by LAA isolation (LAAI) is the underlying mechanism for AF recurrence prevention is still unknown.",
keywords = "Atrial Appendage/surgery, Atrial Fibrillation/physiopathology, Catheter Ablation/methods, Computer Simulation, Heart Conduction System/physiopathology, Humans, Recurrence, Treatment Outcome",
author = "Ali Gharaviri and Simone Pezzuto and Mark Potse and Sander Verheule and Giulio Conte and Rolf Krause and Ulrich Schotten and Angelo Auricchio",
note = "Funding Information: This work was supported by the Swiss National Supercomputing Centre (CSCS project ID s778), by grants to Dr Schotten from the Netherlands Heart Foundation (CVON2014-09, RACE V), and the EU (ERACoSysMED H2020 ERA-NET). Dr Conte is supported by the Swiss National Foundation (SNF; Ambizione grant no PZ00P3_180055/1) Funding Information: This work was supported by the Swiss National Supercomputing Centre (CSCS project ID s778), by grants to Dr Schotten from the Netherlands Heart Foundation (CVON2014-09, RACE V), and the EU (ERACoSysMED H2020 ERA-NET). Dr Conte is supported by the Swiss National Foundation (SNF; Ambizione grant no PZ00P3_180055/1).",
year = "2021",
month = jan,
doi = "10.1161/CIRCEP.120.009230",
language = "English",
volume = "14",
pages = "105--107",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}