Lathouwers, E., Radwan, A., Blommaert, J., Stas, L., Tassignon, B., Allard, SD., De Ridder, F., Hoornaert, N., Lacor, P., Mertens, R., Naeyaert, M., Raeymaekers, H., Seyler, L., Vanbinst, AM., Van Liedekerke, L., Van Schependom, J., Van Schuerbeek, P., Provyn, S., Roelands, B., ... De Pauw, K. (2023). A cross-sectional case-control study on the structural connectome in recovered hospitalized COVID-19 patients (vol 13, 15668, 2023). Scientific reports, 13(1), Article 19012. https://doi.org/10.1038/s41598-023-44726-y

@article{7054fb7c277f40f499f225de13a4ceaa,
title = "A cross-sectional case-control study on the structural connectome in recovered hospitalized COVID-19 patients (vol 13, 15668, 2023)",
abstract = "COVID‑19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness{\textquoteright}s impact on structural brain connectivity, white‑matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross‑sectional study aimed to investigate differences in these factors between former hospitalised COVID‑19 patients (COV) and healthy controls. Group differences in structural brain connectivity were explored using Welch‑two sample t‑tests and two‑sample Mann–Whitney U tests. Multivariate linear models were constructed (one per region) to examine fixel‑based group differences. Differences in cognitive performance between groups were investigated using Wilcoxon Rank Sum tests. Possible effects of bundle‑specific FD measures on cognitive performance were explored using a two‑group path model. No differences in whole‑brain structural organisation were found. Bundle‑specific metrics showed reduced fiber density (p = 0.012, Hedges{\textquoteright} g = 0.884) and fiber density cross‑section (p = 0.007, Hedges{\textquoteright} g = 0.945) in the motor segment of the corpus callosum in COV compared to healthy controls. Cognitive performance on the motor praxis and digit symbol substitution tests was worse in COV than healthy controls (p < 0.001, r = 0.688; p = 0.013, r = 422, respectively). Associations between the cognitive performance and bundle‑specific FD measures differed significantly between groups. WMM and cognitive performance differences were observed between COV and healthy controls. ",
author = "E Lathouwers and A Radwan and J Blommaert and L Stas and B Tassignon and SD Allard and {De Ridder}, F and N Hoornaert and P Lacor and R Mertens and M Naeyaert and H Raeymaekers and L Seyler and AM Vanbinst and {Van Liedekerke}, L and {Van Schependom}, J and {Van Schuerbeek}, P and S Provyn and B Roelands and M Vandekerckhove and R Meeusen and S Sunaert and G Nagels and {De Mey}, J and {De Pauw}, K",
year = "2023",
month = nov,
day = "3",
doi = "10.1038/s41598-023-44726-y",
language = "English",
volume = "13",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}