Van Laethem, D., Laton, J., Rossi, C., Van Schependom, J., & Nagels, G. (2025). Event-related potentials as a potential marker of cognitive fatigability in MS. Multiple Sclerosis Journal, 31(1), 15-15. https://doi.org/10.1177/13524585241306822

@article{12111c8c1c014336a06bafa04228b769,
title = "Event-related potentials as a potential marker of cognitive fatigability in MS",
abstract = "Introduction: 38-83\% of persons with MS suffer from fatigue. Cognitive fatigue or fatigability, a subcategory of fatigue, is defined as the decline of accuracy or reaction times during or after a prolonged cognitive task. This phenomenon is also observed in MS, but little is known about its neurophysiological correlates, specifically event-related potentials (ERP). Objective: Assessing whether cognitive fatigability is related to the amplitude and latency of the auditory oddball potentials N200 and P300. Methods: 23 subjects underwent a 64-channel EEG while performing an auditory oddball task, from which ERPs N200 and P300 were extracted in each channel of the frontocentral midline region (F1, Fz, F2, FC1, FC2, C1, Cz, C2). Latency and amplitude of the largest peak across these channels were selected. Fatigability was defined as the evolution of reaction times (time between oddball presentation and button press) throughout the task, in 2 ways: (1) regression slope of reaction times throughout the task (react-slope); (2) difference between median/mean of the last 15 and the first 15 reaction times (react-diff-median/ react-diff-mean). For both parameters, a higher value means higher fatigability. As participants typically needed time to get used to responding to the target, we removed the first 2 reaction times. Three participants with fewer than 4 responses were removed from analyses. Results: Preliminary results show no significant correlations between fatigabilitiy and N200/P300 amplitude and latency. The strongest correlations were between N200 amplitude, and react- slope (r = -0.254; p = 0.281) and react-diff-median (r = -0.220; p = 0.351). Discussion: N200 amplitude was weakly negatively related to our fatigability measures. Further research is needed to assess if N200 and P300 might be useful biomarkers to identify fatigability and its response to treatment. In this ongoing study, more data will be added, which we expect will improve the significance of our correlations.",
keywords = "biological marker, adult, cognition, conference abstract, controlled study, electroencephalogram, electroencephalography, event related potential, evoked response, fatigue, female, human, latent period, male, multiple sclerosis, normal human, preliminary data, reaction time",
author = "\{Van Laethem\}, D. and J. Laton and C. Rossi and \{Van Schependom\}, J. and G. Nagels",
year = "2025",
month = jan,
day = "27",
doi = "10.1177/13524585241306822",
language = "English",
volume = "31",
pages = "15--15",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "1",
note = "10th Annual Meeting International MS Cognition Society (IMSCOGS), IMSCOGS ; Conference date: 02-09-2024 Through 03-09-2024",
}