Pannone, L., Monaco, C., Della Rocca, D. G., Vergara, P., Sorgente, A., Del Monte, A., Vetta, G., Menè, R., Talevi, G., Eltsov, I., Overeinder, I., Bala, G., Almorad, A., Ströker, E., Pappaert, G., Sieira, J., Gharaviri, A., La Meir, M., Brugada, P., ... de Asmundis, C. (2025). In vivo mapping of human polymorphic ventricular tachycardia. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. https://doi.org/10.1007/s10840-025-02195-5

@article{2d55c0ff8ca34daeb6e0267c4579dc45,
title = "In vivo mapping of human polymorphic ventricular tachycardia",
abstract = "BACKGROUND: Polymorphic ventricular tachycardia (PMVT) is characterized by a typical change in QRS morphology and amplitude. This study aims to evaluate human PMVT mechanisms through in vivo ECG imaging (ECGI) mapping in patients with a normal QTc.METHODS: All patients from UZ Brussel and CHU Bordeaux were screened. The inclusion criterion for the study was PMVT mapped with ECGI. Exclusion criteria were as follows: (1) long QT, (2) premature ventricular contractions inducing PMVT, and (3) acute ischemia. Phase mapping was performed for each PMVT episode, and rotational and focal activity was adjudicated.RESULTS: A total of five patients were analyzed, and five episodes of PMVT were mapped. PMVT duration was 5.9 s, and the cycle length was 242.4 ms. The mean number of rotational activities was 2.5 ± 1.2, with a mean of 2.9 rotations on the apex. The mean number of focal activities was 1.4 ± 0.9. PMVT mechanism was consistent with the following. In the first phase of PMVT, a stable rotor was found over the ventricular apex. The reduction of QRS amplitude in PMVT was associated with the appearance of a non-apical activity. The further reduction of QRS amplitude (trough or minimum) was secondary to a fusion between the apical wavefront and the non-apical wavefront. In the second phase of PMVT, a stable rotational or focal activity was found.CONCLUSION: The main mechanism of human PMVT maintenance was rotational activity over the ventricular apex. Changes in QRS morphology and amplitude were secondary to a fusion between apical and non-apical activities.",
author = "Luigi Pannone and Cinzia Monaco and \{Della Rocca\}, \{Domenico Giovanni\} and Pasquale Vergara and Antonio Sorgente and \{Del Monte\}, Alvise and Giampaolo Vetta and Roberto Men{\`e} and Giacomo Talevi and Ivan Eltsov and Ingrid Overeinder and Gezim Bala and Alexandre Almorad and Erwin Str{\"o}ker and Gudrun Pappaert and Juan Sieira and Ali Gharaviri and \{La Meir\}, Mark and Pedro Brugada and Chierchia, \{Gian Battista\} and Andrea Sarkozy and \{de Asmundis\}, Carlo",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",
year = "2025",
month = dec,
day = "18",
doi = "10.1007/s10840-025-02195-5",
language = "English",
journal = "Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing",
issn = "1383-875X",
publisher = "Springer Netherlands",
}