A detection system for detecting fluorescence lifetime includes an excitation light source configured for repeatedly generating pulsed excitation light, and a detector. The detector has a single-photon detection circuit; a pulse-inhibit circuit for rejecting detected photons that occur outside each one of a series of measurement time windows, each subsequent measurement time window starting after a subsequent excitation light pulse has stopped, and stopping before a next excitation light pulse is generated, each measurement time window having a measurement window period; and a switched-capacitor circuit having an input terminal for receiving a voltage ramp signal that is restarted with each new measurement window period. The switched-capacitor circuit is configured for repetitively computing an average voltage. The switched-capacitor circuit has a node for outputting the computed average voltage as a measure of the fluorescence lifetime.
Kuijk, M, Ingelberts, H & Baijot, CMJ, Circuit and method for fluorescence lifetime imaging, Patent No. US12181408B.
Kuijk, M., Ingelberts, H., & Baijot, C. M. J. (2024). Circuit and method for fluorescence lifetime imaging. (Patent No. US12181408B).
@misc{c507f15c9a984022af321e2e9930b7b6,
title = "Circuit and method for fluorescence lifetime imaging",
abstract = "A detection system for detecting fluorescence lifetime includes an excitation light source configured for repeatedly generating pulsed excitation light, and a detector. The detector has a single-photon detection circuit; a pulse-inhibit circuit for rejecting detected photons that occur outside each one of a series of measurement time windows, each subsequent measurement time window starting after a subsequent excitation light pulse has stopped, and stopping before a next excitation light pulse is generated, each measurement time window having a measurement window period; and a switched-capacitor circuit having an input terminal for receiving a voltage ramp signal that is restarted with each new measurement window period. The switched-capacitor circuit is configured for repetitively computing an average voltage. The switched-capacitor circuit has a node for outputting the computed average voltage as a measure of the fluorescence lifetime.",
author = "Maarten Kuijk and Hans Ingelberts and Baijot, \{C{\'e}dric Martin J\}",
year = "2024",
language = "English",
type = "Patent",
note = "US12181408B",
}