Purpose: This study aimed to evaluate the impact of cartilage damage on knee joint functionality through dynamic CT imaging. Methods or Backround: In an ex-vivo thiel embalmed leg, cartilage was removed progressively from the patellofemoral joint in three stages: Lateral facet, crista and medial facet. After each stage, dynamic CT scans were acquired while inducing a cyclic flexion-extension motion of the leg. Dynamic CT scans were acquired in cine mode with 16 cm z-coverage, 50 cm FOV, 80 kVp, 452 mA, 280 ms rotation time and 6 s total scan duration. Bones were segmented and registered through a multi-atlas approach using SimpleITKElastix. Surface proximity maps of the joint were created to visualise the intraarticular joint space. The intra-articular contact area was computed as the area with a distance to the adjacent bone smaller than the cartilage thickness (5,7 mm). Differences in contact areas between normal and damaged stages were evaluated using a Wilcoxon Signed Rank test. Results or Findings: The contact area after maximum intervention increased from 241 mm2 to 613 mm2 for extension, and from 67 mm2 to 480 mm2 for maximum flexion (p=0.014). Apart from the first stage, each intervention resulted in an increased intra-articular contact area (p=0.02 - 0.014). Conclusion: Dynamic CT scans can indicate an increasing trend of intraarticular contact area with escalating cartilage degeneration.
Acke, M, Scheerlinck, T, Keelson, B, Van Vlasselaer, N, Héréus, S, Van Gompel, G, Cattrysse, E & Buls, N 2024, 'To evaluate the impact of cartilage damage on knee joint functionality through dynamic CT imaging', Insights into Imaging, vol. 15. https://doi.org/10.1186/s13244-024-01766-w
Acke, M., Scheerlinck, T., Keelson, B., Van Vlasselaer, N., Héréus, S., Van Gompel, G., Cattrysse, E., & Buls, N. (2024). To evaluate the impact of cartilage damage on knee joint functionality through dynamic CT imaging. Insights into Imaging, 15. https://doi.org/10.1186/s13244-024-01766-w
@article{512b3430a2894ec9825972e370b20553,
title = "To evaluate the impact of cartilage damage on knee joint functionality through dynamic CT imaging",
abstract = "Purpose: This study aimed to evaluate the impact of cartilage damage on knee joint functionality through dynamic CT imaging. Methods or Backround: In an ex-vivo thiel embalmed leg, cartilage was removed progressively from the patellofemoral joint in three stages: Lateral facet, crista and medial facet. After each stage, dynamic CT scans were acquired while inducing a cyclic flexion-extension motion of the leg. Dynamic CT scans were acquired in cine mode with 16 cm z-coverage, 50 cm FOV, 80 kVp, 452 mA, 280 ms rotation time and 6 s total scan duration. Bones were segmented and registered through a multi-atlas approach using SimpleITKElastix. Surface proximity maps of the joint were created to visualise the intraarticular joint space. The intra-articular contact area was computed as the area with a distance to the adjacent bone smaller than the cartilage thickness (5,7 mm). Differences in contact areas between normal and damaged stages were evaluated using a Wilcoxon Signed Rank test. Results or Findings: The contact area after maximum intervention increased from 241 mm2 to 613 mm2 for extension, and from 67 mm2 to 480 mm2 for maximum flexion (p=0.014). Apart from the first stage, each intervention resulted in an increased intra-articular contact area (p=0.02 - 0.014). Conclusion: Dynamic CT scans can indicate an increasing trend of intraarticular contact area with escalating cartilage degeneration.",
keywords = "aged, cartilage, cartilage degeneration, cartilage thickness, computer assisted tomography, conference abstract, duration, ex vivo study, human, joint cavity, knee joint, male, patellofemoral joint, rotation, Wilcoxon signed ranks test",
author = "M. Acke and T. Scheerlinck and B. Keelson and \{Van Vlasselaer\}, N. and S. H{\'e}r{\'e}us and \{Van Gompel\}, G. and E. Cattrysse and N. Buls",
year = "2024",
month = sep,
day = "1",
doi = "10.1186/s13244-024-01766-w",
language = "English",
volume = "15",
journal = "Insights into Imaging",
issn = "1869-4101",
publisher = "Springer Science and Business Media Deutschland GmbH",
}