Background: Half of PwMS suffer from cognitive deterioration, causing increased burden of disease, but we currently do not have sufficiently strong biomarkers to predict cognitive evolution in MS. Goal: To examine the predictive value of inter- and intrahemispheric coherence connectivity based on source-reconstructed, parcellated magnetoencephalographic (MEG) measurements during an oddball task in relation to cognitive evolution in MS. Results: In total, 100 PwMS were included. Seven were excluded from the analysis because of movement artefacts in the MEG. 81 consented to cognitive retesting after three years. PwMS with worsening cognition after three years showed significant differences in baseline connectivity compared to stable or improving PwMS. Four edges showed a significant difference in coherence at the group level between the cog+ and cog- groups. One of these was intrahemispheric, between the left dorsolateral prefrontal cortex and the left superior frontal cortex. The other three were interhemispheric: between the left superior parietal cortex and the right temporal gyrus, between the left medial occipital and right inferior parietal cortex, and between the left precuneus and right lateral occipital cortex. Conclusion: Inter- and intrahemispheric coherence assessed on source reconstructed and parcellated MEG oddball data is a promising biomarker for cognitive evolution in multiple sclerosis.
Nagels, G, Costers, L, Laton, J & Van Schependom, J 2022, 'Relation between MEG oddball connectivity and cognitive evolution in MS', Multiple Sclerosis Journal, vol. 28, no. 2, pp. 13-13. https://doi.org/10.1177/13524585221100731
Nagels, G., Costers, L., Laton, J., & Van Schependom, J. (2022). Relation between MEG oddball connectivity and cognitive evolution in MS. Multiple Sclerosis Journal, 28(2), 13-13. https://doi.org/10.1177/13524585221100731
@article{939051eaccf646a283bc7aa6ebe38f09,
title = "Relation between MEG oddball connectivity and cognitive evolution in MS",
abstract = "Background: Half of PwMS suffer from cognitive deterioration, causing increased burden of disease, but we currently do not have sufficiently strong biomarkers to predict cognitive evolution in MS. Goal: To examine the predictive value of inter- and intrahemispheric coherence connectivity based on source-reconstructed, parcellated magnetoencephalographic (MEG) measurements during an oddball task in relation to cognitive evolution in MS. Results: In total, 100 PwMS were included. Seven were excluded from the analysis because of movement artefacts in the MEG. 81 consented to cognitive retesting after three years. PwMS with worsening cognition after three years showed significant differences in baseline connectivity compared to stable or improving PwMS. Four edges showed a significant difference in coherence at the group level between the cog+ and cog- groups. One of these was intrahemispheric, between the left dorsolateral prefrontal cortex and the left superior frontal cortex. The other three were interhemispheric: between the left superior parietal cortex and the right temporal gyrus, between the left medial occipital and right inferior parietal cortex, and between the left precuneus and right lateral occipital cortex. Conclusion: Inter- and intrahemispheric coherence assessed on source reconstructed and parcellated MEG oddball data is a promising biomarker for cognitive evolution in multiple sclerosis.",
keywords = "biological marker, artifact, cognition, conference abstract, controlled study, disease burden, dorsolateral prefrontal cortex, frontal cortex, human, inferior parietal cortex, mental deterioration, multiple sclerosis, occipital cortex, parietal cortex, precuneus, predictive value, temporal gyrus",
author = "G. Nagels and L. Costers and J. Laton and {Van Schependom}, J.",
year = "2022",
month = jun,
doi = "10.1177/13524585221100731",
language = "English",
volume = "28",
pages = "13--13",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "2",
}