An in-house developed Label-free Immobilization-free Terahertz(THz) sensor has shown its potential in various applications. In this paper, we present the exper-imental results in the field of High Performance Liquid Chromatography(HPLC) and protein crystallization. Ultra-violet(UV) detectors are very commonly used as a detection technique in HPLC systems. However, it relies on labelling when target substances do not absorb UV light. Therefore it has the drawback of increased cost and time consumption. Our experimental result shows that THz sensor has the potential to replace UV sensor integrated on the HPLC machine as it is able to detect both UV and non-UV absorbing substances without labelling. Meanwhile, the THz sensor is also deployed for the first time to follow protein crystallization process.
Zhang, Y, Matvejev, V, Declerck, S, Stroobants, S, Pandey, G, He, G, Mangelings, D, Maes, D, Muyldermans, S & Stiens, J 2017, Bio-chemical Process Monitoring with Terahertz Sensors. in M Pereira & O Shulika (eds), THz for CBRN and Explosives' Detection and Diagnosis 2017. 1 edn, vol. PartF1, 4, NATO Science for Peace and Security Series B: Physics and Biophysics, Springer, Dordrecht, Netherlands, pp. 29-36. https://doi.org/10.1007/978-94-024-1093-8_4
Zhang, Y., Matvejev, V., Declerck, S., Stroobants, S., Pandey, G., He, G., Mangelings, D., Maes, D., Muyldermans, S., & Stiens, J. (2017). Bio-chemical Process Monitoring with Terahertz Sensors. In M. Pereira, & O. Shulika (Eds.), THz for CBRN and Explosives' Detection and Diagnosis 2017 (1 ed., Vol. PartF1, pp. 29-36). Article 4 (NATO Science for Peace and Security Series B: Physics and Biophysics). Springer. https://doi.org/10.1007/978-94-024-1093-8_4
@inbook{0f3db31620f043e3a212cec50ac15978,
title = "Bio-chemical Process Monitoring with Terahertz Sensors",
abstract = "An in-house developed Label-free Immobilization-free Terahertz(THz) sensor has shown its potential in various applications. In this paper, we present the exper-imental results in the field of High Performance Liquid Chromatography(HPLC) and protein crystallization. Ultra-violet(UV) detectors are very commonly used as a detection technique in HPLC systems. However, it relies on labelling when target substances do not absorb UV light. Therefore it has the drawback of increased cost and time consumption. Our experimental result shows that THz sensor has the potential to replace UV sensor integrated on the HPLC machine as it is able to detect both UV and non-UV absorbing substances without labelling. Meanwhile, the THz sensor is also deployed for the first time to follow protein crystallization process.",
keywords = "THz, biosensors, biochemical changes, Dielectric permittivity, Protein crystallization, HPLC, Millimeter wave",
author = "Yuchen Zhang and Vladimir Matvejev and Sven Declerck and Sander Stroobants and Gokarna Pandey and Guoqiang He and Debby Mangelings and Dominique Maes and Serge Muyldermans and Johan Stiens",
year = "2017",
month = jan,
day = "1",
doi = "10.1007/978-94-024-1093-8\_4",
language = "English",
isbn = "978-94-024-1092-1",
volume = "PartF1",
series = "NATO Science for Peace and Security Series B: Physics and Biophysics",
publisher = "Springer",
pages = "29--36",
editor = "Mauro Pereira and Oleksiy Shulika",
booktitle = "THz for CBRN and Explosives' Detection and Diagnosis 2017",
edition = "1",
}