Willekens, I., Lahoutte, T., Buls, N., Vanhove, C., Deklerck, R., Bossuyt, A., & de Mey, J. (2008). Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC. Mol Imaging Biol, 11(2), 128-135. https://doi.org/10.1007/s11307-008-0186-8

@article{dd2acf31555d41c0b4f499710aa8cfc2,
title = "Time-course of contrast enhancement in spleen and liver with Exia 160, Fenestra LC, and VC",
abstract = "OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice.PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min.RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver.CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.",
keywords = "Animals, Contrast Media, Image Processing, Computer-Assisted, Liver, Male, Metabolic Clearance Rate, Mice, Mice, Inbred C57BL, Nonlinear Dynamics, Spleen, Time Factors, X-Ray Microtomography",
author = "Inneke Willekens and Tony Lahoutte and Nico Buls and Christian Vanhove and Rudi Deklerck and Axel Bossuyt and {de Mey}, Johan",
year = "2008",
month = dec,
day = "11",
doi = "10.1007/s11307-008-0186-8",
language = "English",
volume = "11",
pages = "128--135",
journal = "Mol Imaging Biol",
issn = "1536-1632",
publisher = "Springer New York",
number = "2",
}