Fluorescence imaging has been widely used in fields like (pre)clinical imaging and other domains. With advancements in imaging technology and new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research department is developing the tauCAMTM, based on the Current-Assisted Photonic Sampler, to achieve real-time fluorescence lifetime imaging in the NIR (700–900 nm) region. Incorporating fluorescence lifetime into endoscopy could further improve the differentiation of malignant and benign cells based on their distinct lifetimes. In this work, the capabilities of an endoscopic lifetime imaging system are demonstrated using a rigid endoscope involving various phantoms and an IRF-free deep learning-based method with only 6-time points. The results show that this application{\textquoteright}s fluorescence lifetime image has better lifetime uniformity and precision with 6-time points than the conventional methods.
Iranian, P, Lapauw, T, Van Den Dries, T, Sahakian, S, Wuts, J, Jacobs, VA, Vandemeulebroucke, J, Kuijk, M & Ingelberts, H 2025, 'Fluorescence Lifetime Endoscopy with a Nanosecond Time-Gated CAPS Camera with IRF-Free Deep Learning Method', Sensors, vol. 25, no. 2, 450, pp. 1-23. https://doi.org/10.3390/s25020450
Iranian, P., Lapauw, T., Van Den Dries, T., Sahakian, S., Wuts, J., Jacobs, V. A., Vandemeulebroucke, J., Kuijk, M., & Ingelberts, H. (2025). Fluorescence Lifetime Endoscopy with a Nanosecond Time-Gated CAPS Camera with IRF-Free Deep Learning Method. Sensors, 25(2), 1-23. Article 450. https://doi.org/10.3390/s25020450
@article{73b9ef20359e4a84aa391ef667d39c4a,
title = "Fluorescence Lifetime Endoscopy with a Nanosecond Time-Gated CAPS Camera with IRF-Free Deep Learning Method",
abstract = "Fluorescence imaging has been widely used in fields like (pre)clinical imaging and other domains. With advancements in imaging technology and new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research department is developing the tauCAMTM, based on the Current-Assisted Photonic Sampler, to achieve real-time fluorescence lifetime imaging in the NIR (700–900 nm) region. Incorporating fluorescence lifetime into endoscopy could further improve the differentiation of malignant and benign cells based on their distinct lifetimes. In this work, the capabilities of an endoscopic lifetime imaging system are demonstrated using a rigid endoscope involving various phantoms and an IRF-free deep learning-based method with only 6-time points. The results show that this application{\textquoteright}s fluorescence lifetime image has better lifetime uniformity and precision with 6-time points than the conventional methods.",
keywords = "Endoscopy, fluorescence imaging, fluorescence lifetime imaging, gated camera, CAPS, convolutional neural networks, .",
author = "Pooria Iranian and Thomas Lapauw and {Van Den Dries}, Thomas and Sevada Sahakian and Joris Wuts and Jacobs, {Val{\'e}ry Ann} and Jef Vandemeulebroucke and Maarten Kuijk and Hans Ingelberts",
note = "Publisher Copyright: {\textcopyright} 2025 by the authors.",
year = "2025",
month = jan,
day = "14",
doi = "10.3390/s25020450",
language = "English",
volume = "25",
pages = "1--23",
journal = "Sensors",
issn = "1424-8220",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}