The present invention is related to a method and system for acquiring information on lesions in dynamic 3D medical images of a body region and/or organ. The method comprises the steps of : - applying a registration technique to align a plurality of volumetric image data of the body region and/or organ, yielding multi-phase registered volumetric image data of the body region and/or organ, - applying a hierarchical segmentation on the multi-phase registered volumetric image data of the body region and/or organ, said segmentation yielding a plurality of clusters of n-dimensional voxel vectors of the muiti-phase aligned volumetric image, - determining from the plurality of clusters a cluster or set of clusters delineating the body and/or organ, - identifying the connected region(s) of voxel vectors belonging to the body region and/or organ, - refine/fill the connected region(s); corresponding to the body region and/or organ - reapplying the segmentation step to the refined/filled connected region(s) corresponding to the body region and/or organ, to obtain a more accurate segmentation, - acquiring information on the presence of lesions in a cluster or set of clusters of said plurality of clusters.