Studies increasingly support the idea that fluorescence lifetime imaging (FLI) offers superior tumor detection contrast, but conventional methods are limited by low frame rates and high computational load. We present a compact, real-time FLI system based on a QVGA SPAD sensor with in-pixel switched-capacitor circuits that compute the average photon time-of-arrival in the analog domain. This single-shot, center-of-mass approach avoids photon binning and gated integration, enabling high frame rate FLI up to 30 FPS. Experimental validation with visible (fluorescein and acridine orange) and near-infrared fluorophores (ICG and IRDye800CW), confirms accurate performance. Future work will evaluate the system in preclinical in vivo settings for fluorescence-guided surgical applications.