High-dimensional item response theory analysis of patient-reported outcomes in total knee arthroplasty
 
High-dimensional item response theory analysis of patient-reported outcomes in total knee arthroplasty ■
 
Abel Díaz Berenguer, Abel Díaz Berenguer, Abel Díaz Berenguer, Matías Bossa, Matías Bossa, Matías Bossa, Hichem Sahli, Hichem Sahli, Hichem Sahli, Julien Lebleu, Julien Lebleu, Julien Lebleu, Andries Pauwels, Andries Pauwels, Andries Pauwels
 
Abstract ■

This study introduces a Bayesian multidimensional hierarchical item response theory (MHIRT) model to improve patient-reported outcome (PRO) assessments in total knee arthroplasty (TKA). Traditional unidimensional scoring fails to capture the multifaceted nature of recovery. Our model uncovers latent traits and inter-item relationships directly from PROMs such as the OKS and the EQ-5D-3L, without relying on predefined subscales. MHIRT flexibly decomposes PROMs into clinically meaningful traits like pain, mobility, self-care, and confidence. These traits captured more domain-specific variation, showed stronger sensitivity to temporal changes, and better reflected demographic factors than traditional total scores. The model was trained on a large NHS dataset and externally validated on PROMs from the moveUP digital platform. In predictive modeling of postoperative outcomes, MHIRT-derived features consistently outperformed unidimensional scores and conventional multidimensional IRT models. These findings suggest that MHIRT offers a potentially interpretable framework for tracking recovery and predicting health outcomes.