The detection of suspicious microcalcifications on mammography is usually considered as a primary indication of an early breast cancer. Assessing microcalcifications{\textquoteright} characteristics based on their appearance on 2D mammography is in many cases challenging for radiologists. The aims of this study were to: (a) analyse the association of shape and texture properties of breast microcalcifications (extracted by scanning breast tissue with a high-resolution 3D scanner) with malignancy, (b) evaluate microcalcifications{\textquoteright} potential to diagnose benign/malignant patients.