Soluble HLA-DR antigen levels in serum correlate with rheumatoid arthritis disease activity and the presence of disease-associated epitopes. ■
Leon Verbruggen, Leon Verbruggen, Leon Verbruggen, N. Dumarey, N. Dumarey, N. Dumarey, Hilde Van De Velde, Hilde Van De Velde, Hilde Van De Velde, V. Rebmann, V. Rebmann, V. Rebmann, J. Flament, J. Flament, J. Flament, C. Van Waeyenberge, C. Van Waeyenberge, C. Van Waeyenberge, H. Grosse-Wilde, H. Grosse-Wilde, H. Grosse-Wilde, Christian Demanet, Christian Demanet, Christian Demanet
We investigated correlations between soluble HLA-DR (sHLA-DR) molecules and several clinical, biological and genetic parameters associated with rheumatoid arthritis (RA) disease activity. Serum sHLA-DR concentrations were determined in 146 samples from 89 RA patients by an ELISA format, using an antibody combination of mouse and rat monoclonal anti-human HLA-DR antibodies. The mean sHLA-DR serum level in RA patients was significantly increased with 277±19 ng/ml compared to 142±13 ng/ml of 80 healthy controls (P