Publication Details
Selene De Sutter, Wietse Geens, Matías Bossa, Anne-Marie Vanbinst, Johnny Duerinck, Jef Vandemeulebroucke

Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries

Contribution To Book Anthology


Segmentation of glioma structures is vital for therapy planning. Although state of the art algorithms achieve impressive results when compared to ground-truth manual delineations, one could argue that the binary nature of these labels does not properly reflect the underlying biology, nor does it account for uncertainties in the predicted segmentations. Moreover, the tumor infiltration beyond the contrastenhanced lesion – visually imperceptible on imaging – is often ignored despite its potential role in tumor recurrence. We propose an intensitybased probabilistic model for brain tissue mapping based on conventional MRI sequences. We evaluated its value in the binary segmentation of the tumor and its subregions, and in the visualisation of possible infiltration. The model achieves a median Dice of 0.82 in the detection of the whole tumor, but suffers from confusion between different subregions. Preliminary results for the tumor probability maps encourage further investigation of the model regarding infiltration detection.