Publication Details
Alexander De Cock, Alexander Van Ranst, Costers, Lars, Eva Keytsman, Marie D'hooghe, Miguel D'haeseleer, Nagels, Guy, Jeroen Van Schependom

European Journal of Neurology

Contribution To Journal


OBJECTIVE: Cognitive impairment is common in multiple sclerosis (MS), significantly impacts daily functioning, is time-consuming to assess, and is prone to practice effects. We examined whether the alpha band power measured with magnetoencephalography (MEG) is associated with the different cognitive domains affected by MS.METHODS: Sixty-eight MS patients and 47 healthy controls underwent MEG, T1- and FLAIR-weighted magnetic resonance imaging (MRI), and neuropsychological testing. Alpha power in the occipital cortex was quantified in the alpha1 (8-10?Hz) and alpha2 (10-12?Hz) bands. Next, we performed best subset regression to assess the added value of neurophysiological measures to commonly available MRI measures.RESULTS: Alpha2 power significantly correlated with information processing speed (p?<?0.001) and was always retained in all multilinear models, whereas thalamic volume was retained in 80% of all models. Alpha1 power was correlated with visual memory (p?<?0.001) but only retained in 38% of all models.CONCLUSIONS: Alpha2 (10-12?Hz) power in rest is associated with IPS, independent of standard MRI parameters. This study stresses that a multimodal assessment, including structural and functional biomarkers, is likely required to characterize cognitive impairment in MS. Resting-state neurophysiology is thus a promising tool to understand and follow up changes in IPS.

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